Multifactorial dimensionality reduction (MDR analysis) in genetic research

Tat&#039;yana Lebedz; Nikolay Zhur; Natal&#039;ya Shapialevich

doi:10.62105/2949-6349-2024-1-3-16-21

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MULTIFACTORIAL DIMENSIONALITY REDUCTION (MDR ANALYSIS) IN GENETIC RESEARCH Multifactorial dimensionality reduction (MDR analysis) in genetic research

АА Аа

Published in Russian Journal of Information Technology in Sports · Volume 1, Issue 3 · Pages 16–21 · Rubric: BIOINFORMATICS IN SPORTS

DOI: https://doi.org/10.62105/2949-6349-2024-1-3-16-21 · EDN: YCBQNU

Received: 20.11.2024 Accepted: 08.12.2024 Published: 28.12.2024 Language of publication: RUS

Authors

Tat'yana Lebedz

ORCID SPIN

Nikolay Zhur

Natal'ya Shapialevich

ORCID SPIN

Tat'yana Lebedz

Republican Scientific and Practical Sports Center Research Associate · Laboratory of Biochemistry · Belarus · Minsk

ORCID SPIN

Nikolay Zhur

Polessky State University Assistant · Department of Biochemistry and Bioinformatics · Belarus · Pinsk

Natal'ya Shapialevich

Polessky State University Head of the laboratory · Industry laboratory "Longitudinal studies" · Belarus · Pinsk

ORCID SPIN

ABSTRACT

Based on the assumption that some gene variants in combination may show cumulative or epistatic effects, it is relevant to explore the combination of genotypes of independently acting and interacting polymorphic genes. The article describes the application of nonparametric method of multifactor dimensionality reduction (MDR) on a cohort of highly qualified athletes in order to determine the most preferable combination of genotypes of genes of neurotransmitter systems that determine the functioning of the higher nervous system. Based on the obtained data on the patterns of intergenic interactions, we performed cluster analysis showing the type of interaction between polymorphic loci of neurotransmitter system genes. In addition, we obtained models of the most favorable combination of genotypes for cyclic and acyclic sports. The MDR method in our researches was also applied to identify the unfavorable combination of genotypes in the development of such pathologies as nephropathy and disorder of bone tissue remodeling in young athletes.

KEYWORDS

genetics, genetic research, data analysis, bioinformatics, statistics, intergenic interactions

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1. Kovalevich A., Padutov V., Baranov O. Genome-wide sequencing is a new stage of genetic research. Science and innovation, 2015, 5(147), pp. 56-58. (in Russ.) EDN: https://elibrary.ru/tzfqqx

2. Motsinger A. Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Human Genomics, 2007, 2(5), pp. 318-328. DOI: https://doi.org/10.1186/1479-7364-2-5-318

3. Ponomarenko I.V. Using the method of Multifactor Dimensionality Reduction (MDR) and its modifications for the analysis of gene-gene and gene-environment interactions in genetic and epidemiological studies (review). Scientific results of biomedical research, 2019, 5(1), pp. 4-21. (in Russ.) EDN: https://elibrary.ru/umbgkq

4. Multifactor Dimensionality Reduction [Electronic resource] 24.12.2014. URL: https://sourceforge.net/projects/mdr/ (Access date: 05.11.2024)

5. Shapialevich N.V., Marinich V.V., Melnov S.B. Genetic markers of neurotransmitters and psychophysiological features of qualified athletes of various sports. Applied Sports Science, 2024, 1 (19), pp. 47-54. (in Russ.) URL: https://rep.polessu.by/handle/123456789/31678

6. Zhur N.V., Lebed T.L., Kruchinski N.G. Application of analysis of genetic studies for the diagnosis and prevention of nephrological complications in patients with type 2 diabetes mellitus. Health for all: a scientific and practical journal, 2023, (1), pp. 28-36. (in Russ.) URL: https://rep.polessu.by/handle/123456789/29037

7. Zhur N.V., Evdolyuk S.V., Lebed T.L., Marinich T.V., Kruchinski N.G. Molecular genetic methods in diagnosing and predicting individual predisposition to bone mineral density disorders. Bulletin of the Polessky State University. Natural Sciences Series, 2024, (1), pp. 66-72. (in Russ.) URL: https://rep.polessu.by/handle/123456789/31760

8. Ivaniukovich U., Nikalayenka K., Melnov S., Zhur N., Lebed T. Influence of classification of outcomes on the result of simulation and forecasting by the MDR method. Sakharov Readings 2023: Environmental Problems of the XXI century : proceedings of the 23rd International Scientific Conference, Minsk, Republic of Belarus, May 18-19, 2023. A.D. Sakharov International State Ecological Institute of the Belarusian State University, Minsk : ISEI named after A.D. Sakharov BSU, 2023, (2), pp. 301-305. (in Russ.) URL: https://rep.polessu.by/handle/123456789/28924

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Editor-in-Chief

Egor Timme

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Deputy Editor-in-Chief

Sergey Rudnev

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Scientific Editor

Sergey Simakov

simakovss@ya.ru

Editorial Board member

Albina Andreeva

moymio@yandex.ru

Executive Secretary

Ekaterina Galimova

galim81@mail.ru

Editorial Board member

Anastasia Kovaleva

kovaleva_av@academpharm.ru

Member of the Editorial Board

Elena Skarzhinskaya

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This work is licensed under Creative Commons Attribution 4.0 International Creative Commons

GOST

Lebedz T. L., Zhur N. V., Shapialevich N. V. Multifactorial dimensionality reduction (MDR analysis) in genetic research // Russian Journal of Information Technology in Sports. 2024. no. 3. pp. 16-21. DOI: https://doi.org/10.62105/2949-6349-2024-1-3-16-21. EDN: YCBQNU. (Date of access 28.09.2026).

MLA

Tat'yana Lebedz, Zhur N. V., Shapialevich N. V.. "Multifactorial dimensionality reduction (MDR analysis) in genetic research." Russian Journal of Information Technology in Sports 1.3 (2024): 16-21. DOI: https://doi.org/10.62105/2949-6349-2024-1-3-16-21. EDN: YCBQNU.

APA

Lebedz T. L., Zhur N. V., Shapialevich N. V. (2024). Multifactorial dimensionality reduction (MDR analysis) in genetic research. Russian Journal of Information Technology in Sports, 1(3), 16-21. https://doi.org/10.62105/2949-6349-2024-1-3-16-21 EDN: YCBQNU.

Chicago

Tat'yana Lebedz, Zhur N. V., Shapialevich N. V.. "Multifactorial dimensionality reduction (MDR analysis) in genetic research." Russian Journal of Information Technology in Sports 1, no. 3 (2024): 16-21. https://doi.org/10.62105/2949-6349-2024-1-3-16-21. EDN: YCBQNU.

WIKI

{{cite journal | author = Lebedz T. L., Zhur N. V., Shapialevich N. V. | title = Multifactorial dimensionality reduction (MDR analysis) in genetic research | journal = Russian Journal of Information Technology in Sports | year = 2024 | volume = 1 | issue = 3 | pages = 16-21 | doi = 10.62105/2949-6349-2024-1-3-16-21 }} EDN: YCBQNU

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MULTIFACTORIAL DIMENSIONALITY REDUCTION (MDR ANALYSIS) IN GENETIC RESEARCH Multifactorial dimensionality reduction (MDR analysis) in genetic research

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